Immunogenicity of supplemental doses of poliovirus vaccine for children aged 6–9 months in Moradabad, India: a community-based, randomised controlled trial
نویسندگان
چکیده
Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, GA, USA (C F Estívariz MD, M A Pallansch PhD); National Polio Surveillance Project, RK Khanna Stadium, New Delhi, India (H Jafari MD, H Verma MBBS, S Bahl MD); WHO, Geneva, Switzerland (R W Sutter MD, A Burton BS, R B Aylward MD); Department of Clinical Virology, Christian Medical College, Tamil Nadu, India (Prof T J John FRCP); National Polio Surveillance Project, Central Police Hospital, Moradabad, Uttar Pradesh, India (V Jain MBBS, A Agarwal MBBS); Panacea Biotec Ltd, Mohan Co-op, New Delhi, India (A P Singh MBBS, A Chatterjee MBBS); UNICEF, New Delhi, India (S Guirguis MA); Child Survival Collaborations and Resource Group (CORE), CORE India Consortium, Haryana, India (J Awale MSW)
منابع مشابه
Immunogenicity of supplemental doses of poliovirus vaccine for children aged 6-9 months in Moradabad, India: a community-based, randomised controlled trial.
BACKGROUND The continued presence of polio in northern India poses challenges to the interruption of wild poliovirus transmission and the management of poliovirus risks in the post-eradication era. We aimed to assess the current immunity profile after routine doses of trivalent oral poliovirus vaccine (OPV) and numerous supplemental doses of type-1 monovalent OPV (mOPV1), and compared the effec...
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BACKGROUND Pakistan faces huge challenges in eradicating polio due to widespread poliovirus transmission and security challenges. Innovative interventions are urgently needed to strengthen community buy-in, to increase the coverage of oral polio vaccine (OPV) and other routine immunisations, and to enhance immunity through the introduction of inactivated polio vaccine (IPV) in combination with ...
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PROBLEM Poliovirus transmission remained a public health challenge in western Uttar Pradesh, India in late 2005 and early 2006. In 2006, the India Expert Advisory Group for Polio Eradication concluded that, given the peak incidence of polio among children 6 to 12 months of age, a targeted birth dose of oral polio vaccine may be necessary to interrupt intense poliovirus transmission in high risk...
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Background In 2014, 2 studies showed that inactivated poliovirus vaccine (IPV) boosts intestinal immunity in children previously immunized with oral poliovirus vaccine (OPV). As a result, IPV was introduced in mass campaigns to help achieve polio eradication. Methods We conducted an open-label, randomized, controlled trial to assess the duration of the boost in intestinal immunity following a...
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